Endocrine Abstracts

Background: Acidosis activates the hypothalamic-pituitary-adrenal (HPA) axis and induces glucocorticoid-mediated atrophy of skeletal muscle. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to active cortisol and modulates glucocorticoid signalling locally within skeletal muscle. Here, we address a gap in knowledge how acidosis affects 11β-HSD1 activity in human skeletal muscle cells.Methods: Quadrice...

Background: Immune checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, demonstrating durable responses, but can result in immune-related adverse events (irAEs). Endocrinopathies are amongst the more common adverse events, and thyroid dysfunction and hypophysitis being the most frequent; the latter of these has been positively correlated with oncological outcome. This study compared overall survival (OS), progression-free survival (PFS) and disease c...

Introduction: Hypoglycaemia is a common and serious complication of diabetes treatment especially in patients who do not have knowledge of the condition and personal glucose metres. Patients with very good drug compliance are at greater risk of developing hypoglycaemia. Sometimes hypoglycaemia among patients on insulin therapy could be symptomatic or asymptomatic. The present study is aimed at measuring the determinants and predictors of hypog...

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP) that primarily affects obese women of reproductive age. The aetiology is poorly understood but involves imbalance of cerebrospinal fluid (CSF) secretion and absorption. IIH patients share similar phenotypic characteristics to PCOS patients, a condition with a distinct androgen signature. We hypothesise that obesity and androgen excess maybe...

Background: Hypoglycaemia is a life-threatening condition commonly encountered in emergency department (ED), mainly among individuals with diabetes on insulin or oral hypoglycaemic agents (OHA). Hypoglycaemia in non-diabetic individuals is not a common condition and its often a diagnostic challenge for clinicians especially when presented in an unusual way. Although it does not seem to be a cardiac emergency feature, various electrocardiograph...

Background: Immune checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, demonstrating durable responses, but can result in immune-related adverse events (irAEs). Endocrinopathies are amongst the more common adverse events, and thyroid dysfunction and hypophysitis being the most frequent; the latter of these has been positively correlated with oncological outcome. This study compared overall survival (OS), progression-free survival (PFS) and disease c...

Introduction: Hypoglycaemia is a common and serious complication of diabetes treatment especially in patients who do not have knowledge of the condition and personal glucose metres. Patients with very good drug compliance are at greater risk of developing hypoglycaemia. Sometimes hypoglycaemia among patients on insulin therapy could be symptomatic or asymptomatic. The present study is aimed at measuring the determinants and predictors of hypog...

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure (ICP) that primarily affects obese women of reproductive age. The aetiology is poorly understood but involves imbalance of cerebrospinal fluid (CSF) secretion and absorption. IIH patients share similar phenotypic characteristics to PCOS patients, a condition with a distinct androgen signature. We hypothesise that obesity and androgen excess maybe...

Background: Hypoglycaemia is a life-threatening condition commonly encountered in emergency department (ED), mainly among individuals with diabetes on insulin or oral hypoglycaemic agents (OHA). Hypoglycaemia in non-diabetic individuals is not a common condition and its often a diagnostic challenge for clinicians especially when presented in an unusual way. Although it does not seem to be a cardiac emergency feature, various electrocardiograph...

Case History: A 61 year old woman on haemodialysis with end stage renal failure secondary to immune-complex mediated diffuse proliferative glomerulonephritis was admitted with accelerated hypertension presenting with acute right microvascular 6th nerve palsy and left optic nerve ischaemic atrophy. Her BP had been well controlled over the last 10 years but since the end of 2020 systolic BP readings were frequently recorded above 200mmHg. Multiple antihypertensive classes were c...